Association between neutrophil to lymphocyte ratio and depression among US adults: From a large population-based cross-sectional study

医学 置信区间 全国健康与营养检查调查 优势比 萧条(经济学) 内科学 横断面研究 混淆 中性粒细胞与淋巴细胞比率 病人健康调查表 人口 人口学 淋巴细胞 焦虑 精神科 抑郁症状 病理 经济 社会学 宏观经济学 环境卫生
作者
Moshui Shan,Shan Lü,Rui Cui,Yi Yang,Zhonghua Sun,Yu Pan
出处
期刊:Journal of Psychosomatic Research [Elsevier BV]
卷期号:162: 111041-111041 被引量:10
标识
DOI:10.1016/j.jpsychores.2022.111041
摘要

The study aims to determine the association between neutrophil to lymphocyte ratio (NLR) and depression and severity.We conducted a cross-sectional analysis of the National Health and Nutrition Examination Survey (NHANES). The Patient Health Questionnaire (PHQ-9) was administered to assess depression and its severity. NLR was calculated as a neutrophil count-to-lymphocyte count ratio.The study included 22,207 adults (mean age, 44.43 years; women, 51.05%), and 1671 (6.54%) reported depression. The association between NLR and depression was not significant (odds ratio [OR], 1.06, 95% confidence interval [CI], 0.98 to 1.15, p = 0.12) after fully adjusting the covariates, and similar results (Q1 reference Vs Q2: OR, 0.87, 95%CI, 0.70 to 1.07 Vs Q3: OR, 0.99, 95%CI, 0.80 to 1.21 Vs Q4: OR, 1.08, 95%CI, 0.86 to 1.35, p for trend 0.21) when NLR as a categorical variable. After controlling for all confounding variables, a U-shaped relationship between NLR and depression severity was observed, and the inflection point was 1.78. Subgroup analyses showed a significant association among Mexican American/other Hispanic (OR, 1.13, 95%CI, 1.00 to 1.28, p = 0.04), non-Hispanic blacks (OR, 1.18, 95%CI, 1.07 to 1.32, p = 0.002), the subjects with poverty income ratio above four (OR, 1.24, 95%CI, 1.00 to 1.53, p = 0.048) between NLR and depression. The results from the sensitivity analyses remained stable.The association between NLR and depression is not general across depressed populations among US adults. This association may be specific to subgroups. The relationship between NLR and depression severity is non-linear.
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