The hidden brain-state dynamics of tACS aftereffects

经颅交流电刺激 脑磁图 神经科学 大脑活动与冥想 静息状态功能磁共振成像 脑刺激 动态功能连接 默认模式网络 心理学 刺激 神经影像学 人脑 磁刺激 计算机科学 认知心理学 脑电图 功能磁共振成像
作者
Florian H. Kasten,Christoph S. Herrmann
出处
期刊:NeuroImage [Elsevier BV]
卷期号:264: 119713-119713 被引量:22
标识
DOI:10.1016/j.neuroimage.2022.119713
摘要

Non-invasive techniques to electrically stimulate the brain such as transcranial direct and alternating current stimulation (tDCS/tACS) are increasingly used in human neuroscience and offer potential new avenues to treat brain disorders. Previous research has shown that stimulation effects may depend on brain-states. However, this work mostly focused on experimentally induced brain-states over the course of several minutes. Besides such global, long-term changes in brain-states, previous research suggests, that the brain is likely to spontaneously alternate between states in sub-second ranges, which is much closer to the time scale at which it is generally believed to operate. Here, we utilized Hidden Markov Models (HMM) to decompose magnetoencephalography data obtained before and after tACS into spontaneous, transient brain-states with distinct spatial, spectral and connectivity profiles. Only one out of four spontaneous brain-states, likely reflecting default mode network activity, showed evidence for an effect of tACS on the power of spontaneous α-oscillations. The identified state appears to disproportionally drive the overall (non-state resolved) tACS effect. No or only marginal effects were found in the remaining states. We found no evidence that tACS influenced the time spent in each state. Although stimulation was applied continuously, our results indicate that spontaneous brain-states and their underlying functional networks differ in their susceptibility to tACS. Global stimulation aftereffects may be disproportionally driven by distinct time periods during which the susceptible state is active. Our results may pave the ground for future work to understand which features make a specific brain-state susceptible to electrical stimulation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
李爱国应助科研通管家采纳,获得10
刚刚
科研通AI2S应助科研通管家采纳,获得10
刚刚
搜集达人应助科研通管家采纳,获得10
刚刚
打地鼠工人完成签到,获得积分10
1秒前
彩色半烟完成签到,获得积分10
3秒前
量子星尘发布了新的文献求助10
7秒前
Ning完成签到,获得积分10
10秒前
图图完成签到,获得积分10
10秒前
勤奋的灯完成签到 ,获得积分10
10秒前
ludong_0完成签到,获得积分10
10秒前
Asumita完成签到,获得积分10
11秒前
双青豆完成签到 ,获得积分10
11秒前
13秒前
fxy完成签到 ,获得积分10
14秒前
合适的幻然完成签到,获得积分10
14秒前
沐雨汐完成签到,获得积分10
16秒前
18秒前
19秒前
jiayoujijin完成签到 ,获得积分10
19秒前
淡然思卉完成签到,获得积分10
20秒前
争当科研巨匠完成签到,获得积分10
20秒前
英姑应助认真的刺猬采纳,获得10
27秒前
好大一只小坏蛋完成签到,获得积分20
27秒前
站走跑完成签到 ,获得积分10
30秒前
步步高完成签到,获得积分10
32秒前
无私的雪瑶完成签到 ,获得积分10
32秒前
小杨完成签到,获得积分20
33秒前
小花完成签到 ,获得积分10
38秒前
宁夕完成签到 ,获得积分10
42秒前
西宁完成签到,获得积分10
42秒前
拼搏的羊青完成签到 ,获得积分10
43秒前
科目三应助asd113采纳,获得10
43秒前
deng203完成签到 ,获得积分20
45秒前
46秒前
时米米米完成签到,获得积分10
46秒前
浅浅完成签到,获得积分10
50秒前
量子星尘发布了新的文献求助10
55秒前
帅气的藏鸟完成签到,获得积分10
59秒前
加油完成签到 ,获得积分10
1分钟前
健康的宛菡完成签到 ,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038066
求助须知:如何正确求助?哪些是违规求助? 3575779
关于积分的说明 11373801
捐赠科研通 3305584
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022