Complementarity of two approaches based on the use of high-resolution mass spectrometry for the determination of multi-class antibiotics in water. Photodegradation studies and non-target screenings

色谱法 化学 质谱法 光降解 磺胺二甲氧嘧啶 吸附剂 洗脱 废水 固相萃取 萃取(化学) 样品制备 生物分析 环境化学 环境科学 光催化 有机化学 环境工程 催化作用 吸附
作者
Lúa Vázquez,Marı́a Llompart,Thierry Dagnac
出处
期刊:Environmental Science and Pollution Research [Springer Nature]
卷期号:30 (1): 1871-1888 被引量:4
标识
DOI:10.1007/s11356-022-22130-9
摘要

Abstract The development of analytical methodologies to monitor different antibiotic families in water and the implementation of alternatives for their efficient elimination are a great challenge. The aim of this research was to develop a method based on solid-phase extraction followed by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry to analyse multi-class antibiotics, including macrolides, cephalosporins, fluoroquinolones, sulfonamides and diaminopyrimidines, in waters. Several parameters affecting the extraction such as the sample pH, type of sorbent and cartridge, elution volume and breakthrough volume were optimized. The method was validated in real samples, and matrix effect was assessed, demonstrating that the use of isotopically labelled surrogate compounds was mandatory to avoid standard addition calibration for each individual samples. Urban and hospital wastewater samples, as well as natural waters, were analysed, confirming the presence of 12 of the 14 target compounds at concentrations up to 3.5 µg L −1 . Non-target analysis based on data-independent workflow was also performed, enabling the identification of 94 pollutants. Preliminary photodegradation experiments were also assessed, revealing the total removal of many target compounds after the first 5–10 min of UVC irradiation. In addition, 20 by-products formed after photolysis could be identified using a non-target approach.
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