计算机科学
数据集成
蛋白质组学
生物网络
生物学数据
蛋白质组
吞吐量
组学
计算生物学
数据科学
系统生物学
蛋白质基因组学
基因组学
数据挖掘
生物信息学
生物
基因组
电信
基因
生物化学
无线
作者
Hsueh‐Fen Juan,Hsuan‐Cheng Huang
摘要
Abstract The study of multiple “omes,” such as the genome, transcriptome, proteome, and metabolome has become widespread in biomedical research. High‐throughput techniques enable the rapid generation of high‐dimensional multiomics data. This multiomics approach provides a more complete perspective to study biological systems compared with traditional methods. However, the quantitative analysis and integration of distinct types of high‐dimensional omics data remain a challenge. Here, we provide an up‐to‐date and comprehensive review of the methods used for omics data quantification and integration. We first review the quantitative analysis of not only bulk but also single‐cell transcriptomics data, as well as proteomics data. Current methods for reducing batch effects and integrating heterogeneous high‐dimensional data are then introduced. Network analysis on large‐scale biomedical data can capture the global properties of drugs, targets, and disease relationships, thus enabling a better understanding of biological systems. Current trends in the applications and methods used to extend quantitative omics data analysis to biological networks are also discussed. This article is categorized under: Data Science > Artificial Intelligence/Machine Learning
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