碳水化合物反应元件结合蛋白
葡萄糖激酶
下调和上调
全基因组关联研究
生物
调节器
转录因子
基因
细胞生物学
遗传学
单核苷酸多态性
基因型
作者
Charandeep Singh,Byungchang Jin,Nirajan Shrestha,Andrew L. Markhard,Apekshya Panda,Sarah E. Calvo,Amy Deik,Xingxiu Pan,Austin L. Zuckerman,Amel Ben Saad,Kathleen E. Corey,Julia Sjoquist,Stephanie A. Osganian,Roya AminiTabrizi,Eugene P. Rhee,Hardik Shah,Olga Goldberger,Alan C. Mullen,Valentin Cracan,Clary B. Clish,Vamsi K. Mootha,Russell P. Goodman
出处
期刊:Cell Metabolism
[Elsevier]
日期:2024-01-01
卷期号:36 (1): 144-158.e7
被引量:2
标识
DOI:10.1016/j.cmet.2023.11.010
摘要
Common genetic variants in glucokinase regulator (GCKR), which encodes GKRP, a regulator of hepatic glucokinase (GCK), influence multiple metabolic traits in genome-wide association studies (GWASs), making GCKR one of the most pleiotropic GWAS loci in the genome. It is unclear why. Prior work has demonstrated that GCKR influences the hepatic cytosolic NADH/NAD
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