Pathogenic Variants of Scavenger Receptor CD36 Lead to Decreased Efferocytosis and Predispose to Myocarditis Following Vaccination With Pfizer-BioNTech BNT162b2 Against Coronavirus Infection (COVID-19)

HomeCirculationVol. 149, No. 3Pathogenic Variants of Scavenger Receptor CD36 Lead to Decreased Efferocytosis and Predispose to Myocarditis Following Vaccination With Pfizer-BioNTech BNT162b2 Against Coronavirus Infection (COVID-19) No AccessResearch ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessResearch ArticleRequest AccessFull TextPathogenic Variants of Scavenger Receptor CD36 Lead to Decreased Efferocytosis and Predispose to Myocarditis Following Vaccination With Pfizer-BioNTech BNT162b2 Against Coronavirus Infection (COVID-19) Christina Canavati, Ahmad Siam, Sapir Labes, Nirit Trabelsi, Eshcar Regev, Elchanan Parnasa, Barhoum Barhoum, Nur Magadle, Ofer Perzon, Maya Braun, Hagar Mor-Shaked, Ora Schueler-Furman, Yuval Tabach and Dror Mevorach Christina CanavatiChristina Canavati Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada (C.C., S.L., M.B., Y.T.), Jerusalem, Israel. Hebrew University-Hadassah Faculty of Medicine (C.C., S.L., H.M.-S., Y.T., D.M.), Jerusalem, Israel. , Ahmad SiamAhmad Siam The Wohl Institute for Translational Medicine (A.S., E.R., E.P., B.B., N.M., O.P., D.M.)., Hadassah-Hebrew University Medical Center, Jerusalem, Israel. , Sapir LabesSapir Labes Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada (C.C., S.L., M.B., Y.T.), Jerusalem, Israel. Hebrew University-Hadassah Faculty of Medicine (C.C., S.L., H.M.-S., Y.T., D.M.), Jerusalem, Israel. , Nirit TrabelsiNirit Trabelsi Department of Microbiology and Molecular Genetics, IMRIC (N.T., O.S.F.), Jerusalem, Israel. , Eshcar RegevEshcar Regev The Wohl Institute for Translational Medicine (A.S., E.R., E.P., B.B., N.M., O.P., D.M.)., Hadassah-Hebrew University Medical Center, Jerusalem, Israel. , Elchanan ParnasaElchanan Parnasa The Wohl Institute for Translational Medicine (A.S., E.R., E.P., B.B., N.M., O.P., D.M.)., Hadassah-Hebrew University Medical Center, Jerusalem, Israel. , Barhoum BarhoumBarhoum Barhoum The Wohl Institute for Translational Medicine (A.S., E.R., E.P., B.B., N.M., O.P., D.M.)., Hadassah-Hebrew University Medical Center, Jerusalem, Israel. , Nur MagadleNur Magadle https://orcid.org/0000-0002-4146-0754 The Wohl Institute for Translational Medicine (A.S., E.R., E.P., B.B., N.M., O.P., D.M.)., Hadassah-Hebrew University Medical Center, Jerusalem, Israel. , Ofer PerzonOfer Perzon https://orcid.org/0000-0001-9402-9039 The Wohl Institute for Translational Medicine (A.S., E.R., E.P., B.B., N.M., O.P., D.M.)., Hadassah-Hebrew University Medical Center, Jerusalem, Israel. , Maya BraunMaya Braun https://orcid.org/0000-0002-9307-5081 Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada (C.C., S.L., M.B., Y.T.), Jerusalem, Israel. , Hagar Mor-ShakedHagar Mor-Shaked https://orcid.org/0000-0001-6631-0376 Hebrew University-Hadassah Faculty of Medicine (C.C., S.L., H.M.-S., Y.T., D.M.), Jerusalem, Israel. Department of Genetics, Hadassah Medical Center, Jerusalem, Israel (H.M.-S.). , Ora Schueler-FurmanOra Schueler-Furman https://orcid.org/0000-0002-1624-0362 Department of Microbiology and Molecular Genetics, IMRIC (N.T., O.S.F.), Jerusalem, Israel. , Yuval TabachYuval Tabach https://orcid.org/0000-0001-9521-3217 Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada (C.C., S.L., M.B., Y.T.), Jerusalem, Israel. Hebrew University-Hadassah Faculty of Medicine (C.C., S.L., H.M.-S., Y.T., D.M.), Jerusalem, Israel. and Dror MevorachDror Mevorach Correspondence to: Dror Mevorach, MD, Director of the Institute of Rheumatology-Immunology-Allergology, the Wohl Institute for Translational Medicine, Department of Medicine, POB 12000, Hadassah Medical Center, Jerusalem, Israel. Email E-mail Address: [email protected] https://orcid.org/0000-0001-8096-9900 Hebrew University-Hadassah Faculty of Medicine (C.C., S.L., H.M.-S., Y.T., D.M.), Jerusalem, Israel. The Wohl Institute for Translational Medicine (A.S., E.R., E.P., B.B., N.M., O.P., D.M.)., Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Institute of Rheumatology-Immunology-Allergology and Department of Medicine (D.M.), Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Originally published16 Jan 2024https://doi.org/10.1161/CIRCULATIONAHA.123.064884Circulation. 2024;149:270–273FootnotesFor Sources of Funding and Disclosures, see page 273.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Dror Mevorach, MD, Director of the Institute of Rheumatology-Immunology-Allergology, the Wohl Institute for Translational Medicine, Department of Medicine, POB 12000, Hadassah Medical Center, Jerusalem, Israel. Email mevorachd@gmail.comREFERENCES1. Mevorach D, Anis E, Cedar N, Bromberg M, Haas EJ, Nadir E, Olsha-Castell S, Arad D, Hasin T, Levi N, et al. Myocarditis after BNT162b2 mRNA vaccine against Covid-19 in Israel.N Engl J Med. 2021; 385:2140–2149. doi: 10.1056/NEJMoa2109730CrossrefMedlineGoogle Scholar2. Hirano K, Kuwasako T, Nakagawa-Toyama Y, Janabi M, Yamashita S, Matsuzawa Y. Pathophysiology of human genetic CD36 deficiency.Trends Cardiovasc Med. 2003; 13:136–141. doi: 10.1016/s1050-1738(03)00026-4CrossrefMedlineGoogle Scholar3. Labes S, Stupp D, Wagner N, Bloch I, Lotem M, E LL, Polak P, Pupko T, Tabach Y. Machine-learning of complex evolutionary signals improves classification of SNVs.NAR Genom Bioinform. 2022; 4:lqac025. doi: 10.1093/nargab/lqac025CrossrefMedlineGoogle Scholar4. Lafuse WP, Wozniak DJ, Rajaram MVS. Role of cardiac macrophages on cardiac inflammation, fibrosis and tissue repair.Cells. 2020; 10:51. doi: 10.3390/cells10010051CrossrefMedlineGoogle Scholar5. Tsaban T, Stupp D, Sherill-Rofe D, Bloch I, Sharon E, Schueler-Furman O, Wiener R, Tabach Y. CladeOScope: functional interactions through the prism of clade-wise co-evolution.NAR Genom Bioinform. 2021; 3:lqab024. doi: 10.1093/nargab/lqab024CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. 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