Coaxial Bright and Dark Field Optical Coherence Tomography

光学 光学相干层析成像 斑点图案 同轴 信号(编程语言) 光圈(计算机存储器) 光学层析成像 信噪比(成像) 物理 计算机科学 电信 声学 程序设计语言
作者
Yukun Wang,Si Chen,Xi Chen,Zhengyang Xu,Kan Lin,Linlin Shi,Quanquan Mu,Linbo Liu
出处
期刊:IEEE Transactions on Biomedical Engineering [Institute of Electrical and Electronics Engineers]
卷期号:71 (6): 1879-1888 被引量:1
标识
DOI:10.1109/tbme.2024.3355174
摘要

To improve the signal collection efficiency of Optical Coherence Tomography (OCT) for biomedical applications. A novel coaxial optical design was implemented, utilizing a wavefront-division beam splitter in the sample arm with a 45-degree rod mirror. This design allowed for the simultaneous collection of bright and dark field signals. The bright field signal was detected within its circular aperture in a manner similar to standard OCT, while the dark field signal passed through an annular-shaped aperture and was collected by the same spectrometer via a fiber array. This new configuration improved the signal collection efficiency by ∼3 dB for typical biological tissues. Dark-field OCT images were found to provide higher resolution, contrast and distinct information compared to standard bright-field OCT. By compounding bright and dark field images, speckle noise was suppressed by ∼ $\sqrt{2}$ . These advantages were validated using Teflon phantoms, chicken breast ex vivo, and human skin in vivo. This new OCT configuration significantly enhances signal collection efficiency and image quality, offering great potential for improving OCT technology with better depth, contrast, resolution, speckles, and signal-to-noise ratio. We believe that the bright and dark field signals will enable more comprehensive tissue characterization with the angled scattered light. This advancement will greatly promote the OCT technology in various clinical and biomedical research applications.
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