The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cells

(Cancer Cell 41, 1927–1944; November 13, 2023) This article reports that tumor-resident fungi Aspergillus sydowii can promote lung adenocarcinoma progression. The labels in Figure 2K were inadvertently mislabeled. The cyan color should be labelled as “A. sydowii” and the orange color should be labelled as “AmB”. In addition, the word “intratracheal” in Figure S5A was mistakenly used and now has been corrected to “intratumor” to match the legend. Finally, legends to Figures S5N & S5O were missing and now added in the corrected supplemental PDF file of the paper. We, the authors, note that these errors were introduced during revision and final figure preparation and did not affect the conclusions of the article. We apologize for any inconvenience caused by these errors.Figure 2. Tumor-resident A. sydowii promotes lung tumor progression by inducing an immunosuppressive TME (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure S5. A. sydowii did not promote the immunosuppressive activity of M2 macrophages, related to Figure 2 and Figure 3 (original)View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure S5. A. sydowii did not promote the immunosuppressive activity of M2 macrophages, related to Figure 2 and Figure 3 (corrected)View Large Image Figure ViewerDownload Hi-res image Download (PPT) The intratumor mycobiome promotes lung cancer progression via myeloid-derived suppressor cellsLiu et al.Cancer CellSeptember 21, 2023In BriefLiu et al. find that Aspergillus sydowii, the enriched tumor-resident fungus, promotes lung adenocarcinoma progression by inducing MDSCs expansion and activation through IL-1β secretion via β-glucan-mediated Dectin-1/CARD9 pathway. These findings identify the intratumor mycobiome, despite their low abundance, promotes tumor progression by inducing an immunosuppressive TME. Full-Text PDF