驻极体
材料科学
肌成纤维细胞
生物医学工程
刺激
电穿孔
电场
纳米技术
光电子学
生物物理学
医学
化学
神经科学
复合材料
生物
纤维化
病理
生物化学
物理
量子力学
基因
作者
Sung‐Won Kim,Sumin Cho,Dong Soo Lee,Jiyu Hyun,Sunmin Jang,Inwoo Seo,Hyun Su Park,Hee Jae Hwang,Hyung‐Seop Han,Dae Hyeok Yang,Heung Jae Chun,Suk Ho Bhang,Dongwhi Choi
出处
期刊:InfoMat
[Wiley]
日期:2023-10-26
卷期号:6 (3)
被引量:2
摘要
Abstract Electrical stimulation has recently received attention as noninvasive treatment in skin wound healing with its outstanding biological property for clinical setting. However, the complexity of equipment for applying appropriate electrical stimulation remains an ongoing challenge. Here, we proposed a strategy for skin scar inhibition by providing electrical stimulation via a multilayer stacked electret (MS‐electret), which can generate direct current (DC) electric field (EF) without any power supply equipment. In addition, the MS‐electret can easily control the intensity of EFs by simply stacking electret layers and maintain stable EF with the surface potential of 3400 V over 5 days owing to the injected charges on the electret surface. We confirmed inhibition of type 1 collagen and α‐SMA expression of human dermal fibroblasts (hDFs) by 90% and 44% in vitro, indicating that the transition of hDFs to myofibroblasts was restricted by applying stable electrical stimulation. We further revealed a 20% significant decrease in the ratio of myofibroblasts caused by the MS‐electret in vivo. These findings present that the MS‐electret is an outstanding candidate for effective skin scar inhibition with a battery‐free, physiological electrical microenvironment, and noninvasive treatment that allows it to prevent external infection. image
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