Efficient Synthesis of N‐Pyridinylamides Using a Bimetallic Co/Fe‐Metal‐Organic Framework Heterogeneous Catalyst

Abstract The synthesis of N‐pyridinylamides has been realized by particularly efficient technologies via bimetallic organic (Co/Fe‐MOF) catalyzed oxidative amidation between 2‐aminopyridine and benzaldehyde. The C−N bond was formed with the presence of a catalyst (Co/Fe‐MOF) as a Lewis acid and the oxidant as DTBP. The oxidative amidation reaction was conducted in 1,4‐dioxane at 120 °C with a wide range of substrates producing the corresponding amide products in good to 94 % yields. Experimental results illustrated that This accessibly offers a significant improvement over the earlier successful attempts in forming N‐pyridinyl amides . The Co/Fe‐MOF material was synthesized by solvothermal methods with the salt mixture of Fe(NO 3 ) 3 .9H 2 O and Co(NO 3 ) 2 .6H 2 O. The material was determined by modern analytic methods like X‐ray diffraction (XRD), Fourier‐transform Infrared spectroscopy (FT‐IR), Scanning Electron Microscope (SEM), and N 2 adsorption/desorption isotherms.