Law of diffusion bubbles produced by high-voltage pulsed electric field in liquid

材料科学 烧蚀 阳极 电场 电极 脉搏(音乐) 电压 气泡 扩散 波形 阴极 核磁共振 光学 光电子学 电气工程 机械 物理 医学 热力学 内科学 工程类 量子力学
作者
Xiaodong Wu,Yan-Zhou Chen,Rui Han,Yu-Yi Guo,Jie Zhuang,Fu-Kun Shi
出处
期刊:Chinese Physics [Science Press]
卷期号:72 (21): 214701-214701
标识
DOI:10.7498/aps.72.20230443
摘要

Pulsed electric field is a novel physical energy source for treating atrial fibrillation and tumor ablation, which has advantages over traditional thermal ablation, such as being non-thermal, short treatment time, tissue selectivity, and low contact pressure requirements. The diffusion bubbles generated during physical ablation may lead to gas embolism and silent cerebral events, with potential hazards such as tissue damage and cerebral ischemia. Previous studies have shown that the number of bubbles generated is correlated with the electrical properties of the treated object, pulse parameters (pulse waveform, treatment time and input energy), and electrodes. The number of bubbles are more significant at the cathode than at the anode, and the number of bubbles positively correlates with the input energy. However, to the best of our knowledge, no studies have been conducted to investigate the effects of ablation pulse parameters on diffusion bubbles. Therefore, in our experiment, a platform for producing pulses and observing diffusion bubble is built, and the needle-ring electrode we made realizes the capture and measurement of diffusion bubbles. Since pulses with a voltage of 3 kV and a pulse width of 100 μs are commonly used as ablation parameters for atrial fibrillation and tumor in pulsed field ablation (PFA), the pulse width of unipolar pulse is selected as 5, 10, 50, and 100 μs, and the number of pulses applied is 1. The pulse voltage is determined according to the parameters commonly used in PFA and the simulation calculation of the field strength distribution of the needle-ring electrode. After determining the parameters, this experiment explicitly investigates the relationships among diffusion bubbles and solution conductivity, pulse voltage, pulse width, input energy, and other parameters. Meanwhile, the size distributions of diffusion bubbles under different operating conditions are statistically investigated. Besides, the possible causes of diffuse bubbles are also explored. We evaluate the number of bubbles by measuring the cross-sectional area of the diffusion bubbles from a top-down perspective. The experimental results show that the area of diffusion bubbles generated in the liquid is positively correlated with pulse voltage and input energy; high conductivity and long pulse width can enhance the thermal effect and increase the area of diffusion bubbles; diffusion bubbles with a diameter larger than 100 μm are easily generated under high conductivity and high pulse width conditions. By speculating on the results, the electrolytic reaction may be the main source of diffusion bubbles when the needle electrode is the cathode. This study is expected to optimize future pulsed electric field ablation parameters.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
YL完成签到,获得积分10
2秒前
NexusExplorer应助小王采纳,获得10
3秒前
3秒前
sl完成签到,获得积分10
3秒前
CC完成签到,获得积分10
4秒前
自信松思完成签到 ,获得积分10
5秒前
荣枫完成签到,获得积分10
5秒前
5秒前
火火火木完成签到 ,获得积分10
6秒前
大模型应助妖孽宇采纳,获得10
6秒前
8秒前
积极行天发布了新的文献求助50
8秒前
受伤凌蝶发布了新的文献求助10
11秒前
fusucheng完成签到,获得积分10
12秒前
koi完成签到,获得积分20
12秒前
12秒前
聪明摩托完成签到,获得积分10
12秒前
阿纯完成签到,获得积分10
13秒前
14秒前
肱二头肌完成签到,获得积分10
15秒前
16秒前
小王发布了新的文献求助10
16秒前
多情自古空余恨完成签到,获得积分10
17秒前
Qionglin完成签到,获得积分10
19秒前
Bao完成签到 ,获得积分10
20秒前
20秒前
初夏微凉发布了新的文献求助30
20秒前
21秒前
书霂完成签到,获得积分10
21秒前
优秀含羞草完成签到,获得积分10
22秒前
宓沂完成签到,获得积分10
22秒前
vivre223完成签到,获得积分10
22秒前
量子星尘发布了新的文献求助10
23秒前
受伤凌蝶完成签到,获得积分10
24秒前
wenjiejiang完成签到,获得积分10
25秒前
25秒前
zly完成签到 ,获得积分10
26秒前
26秒前
李某人完成签到,获得积分10
26秒前
27秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029