Exploring the potential of the nano-based sunscreens and antioxidants for preventing and treating skin photoaging

光老化 光防护 紫外线滤光片 皮肤老化 皮肤病科 抗氧化剂 化学 人体皮肤 皮肤癌 药理学 医学 生物化学 光合作用 物理 癌症 生物 内科学 光学 遗传学
作者
Chih-Hung Lin,Ming‐Hsien Lin,Yu-Kuo Chung,Ahmed Alalaiwe,Chi‐Feng Hung,Jia‐You Fang
出处
期刊:Chemosphere [Elsevier BV]
卷期号:347: 140702-140702 被引量:15
标识
DOI:10.1016/j.chemosphere.2023.140702
摘要

Excessive exposure to sunlight, especially UV irradiation, causes skin photodamage. Sunscreens, such as TiO2 and ZnO, can potentially prevent UV via scattering, reflection, and absorption. Topical antioxidants are another means of skin photoprotection. Developing nanoparticles for sunscreens and antioxidants is recommended for photoaging prevention and treatment as it can improve uncomfortable skin appearance, stability, penetration, and safety. This study reviewed the effects of nano-sized sunscreens and antioxidants on skin photoprevention by examining published studies and articles from PubMed, Scopus, and Google Scholar, which explore the topics of skin photoaging, skin senescence, UV radiation, keratinocyte, dermal fibroblast, sunscreen, antioxidant, and nanoparticle. The researchers of this study also summarized the nano-based UV filters and therapeutics for mitigating skin photoaging. The skin photodamage mechanisms are presented, followed by the introduction of current skin photoaging treatment. The different nanoparticle types used for topical delivery were also explored in this study. This is followed by the mechanisms of how nanoparticles improve the UV filters and antioxidant performance. Lastly, recent investigations were reviewed on nanoparticulate sunscreens and antioxidants in skin photoaging management. Sunscreens and antioxidants for topical application have different concepts. Topical antioxidants are ideal for permeating into the skin to exhibit free radical scavenging activity, while UV filters are prescribed to remain on the skin surface without absorption to exert the UV-blocking effect without causing toxicity. The nanoparticle design strategy for meeting the different needs of sunscreens and antioxidants is also explored in this study. Although the benefits of using nanoparticles for alleviating photodamage are well-established, more animal-based and clinical studies are necessary.
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