小泡
心磷脂
荧光
脂质体
两亲性
化学
生物物理学
膜
纳米技术
材料科学
生物化学
有机化学
磷脂
生物
光学
物理
共聚物
聚合物
作者
Shujiao Chen,Z. X. Liu,Bifei Li,Yi Hou,Y. Y. Peng,Jianhui Li,Qunhui Yuan,Wei Gan
摘要
Investigating the influence of the ambient chemical environment on molecular behaviors in liposomes is crucial for understanding and manipulating cellular vitality as well as the capabilities of lipid drug carriers in various environments. Here, we designed and synthesized a second harmonic generation (SHG) and fluorescence probe molecule called Pyr-Py+-N+ (PPN), which possesses membrane-targeting capability. We employed PPN to investigate the response of lipid vesicles composed of cardiolipin to the presence of exogenous salt. The kinetic behaviors, including the adsorption and embedding of PPN on the surface of small unilamellar vesicles (SUVs) composed of cardiolipin, were analyzed. The response of the SUVs to the addition of NaCl was also monitored. A rapid decrease in vesicle size can be evidenced through the rapid drop in SHG emission originating from PPN located on the vesicle surface.
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