循环肿瘤细胞
医学
乳腺癌
转移性乳腺癌
免疫系统
癌症
内科学
液体活检
肿瘤科
生物标志物
三阴性乳腺癌
病理
转移
免疫学
生物
生物化学
作者
Cvetka Grašič Kuhar,Julie Silvester,Marina Mencinger,Tanja Ovčariček,Maja Čemažar,Simona Miceska,Živa Modic,Anamarija Kuhar,Tanja Jesenko,Veronika Kloboves Prevodnik
出处
期刊:Cancers
[MDPI AG]
日期:2023-06-28
卷期号:15 (13): 3397-3397
被引量:4
标识
DOI:10.3390/cancers15133397
摘要
Liquid biopsy is becoming an important source of new biomarkers during the treatment of metastatic cancer patients. Using size-based microfluid technology, we isolated circulating tumor cells (CTCs) from metastatic breast cancer patients to evaluate their presence and cluster formation, as well as the presence of megakaryocytes and immune-inflammatory blood cells, and to correlate their presence with clinicopathological data and overall survival (OS). In total, 59 patients (median age 60.4 years) were included in the study: 62.7% luminal A/B-like, 20.3% HER2-positive, and 17% triple-negative. Our results showed that at least one CTC was present in 79.7% and ≥5 CTCs in 35.2% of the patients. CTC clusters were present in patients with ≥5 CTCs only (in 19.2% of them), and megakaryocytes were present in 52% of all patients. The presence of CTC clusters and megakaryocytes was positively associated with the CTC count. Patients with low pan-inflammatory value (PIV), low systemic immune-inflammatory index (SII), and low relative change from baseline (ΔPIV%, ΔSII%) were associated with significantly higher OS than their counterparts. ΔPIV%, the presence of infection in the last month, and a long duration of metastatic disease were identified as independent prognostic factors for OS. The interplay of CTCs, CTC clusters, megakaryocytes, and PIV needs to be further explored.
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