Alignment Strategies in Total Knee Arthroplasty: The Rise and Role of Enabling Technology

Abstract Total knee arthroplasty (TKA) remains the gold standard surgical care for end-stage knee arthritis. Since its inception, TKA has seen many transformative factors with advances in material properties, implant design, and fixation. Improvements in implant longevity has culminated in TKA being recognized as one of modern medicine's most successful surgical procedures. Patient satisfaction, however, remains a significant challenge. Recent studies report that patient satisfaction with current implants and techniques remains at 80 to 90%, suggesting that up to one in five patients remain dissatisfied with their procedure. A balanced knee, defined as equal medial and lateral gaps in knee extension and flexion, is a desired outcome in TKA. This has been shown to be associated with improved clinical outcomes. Given the poor rate of surgeon-defined balance, intraoperative knee balance can be confirmed with objective load data using sensor-embedded smart inserts or by measuring gaps using computer-assisted or robotic platforms. Currently, there is no consensus on the correct alignment or laxity targets for individualized alignment strategies in TKA, and further research in this area is required to answer this. Tremendous advances in our understanding of knee anatomy and kinematics have come to light in the recent past, and these insights have spawned interest in alternative alignment techniques in TKA. More recently, an appreciation of individual knee phenotypes and associated classification systems have provided a platform and the scientific justification behind these contemporary alignment strategies. Paired with enabling technologies, it is becoming an accepted paradigm that surgeons have the ability to select a desired alignment target when undertaking an individualized alignment strategy in TKA and execute the surgery with a high degree of precision. It is hoped that this may reduce the rate of dissatisfaction following TKA and improve clinical outcomes. This review article provides an overview of the concepts of knee phenotypes, current alignment strategies in TKA, and the emerging benefits of enabling technologies.