伤口愈合
化学
分离(微生物学)
DNA
细胞生物学
小泡
细胞外小泡
细胞外
生物化学
生物物理学
微生物学
生物
免疫学
膜
作者
Tong Zhu,Boyue Fan,Ziju He,Zeyu Fan,Bangshun He,Wenjun Miao,Rongrong Huang
标识
DOI:10.1021/acs.biomac.4c00398
摘要
Platelet-derived extracellular vesicles (PEVs) showing great potential in wound healing have attracted increasing attention recently. Nondestructive isolation and effective utilization strategies are highly conducive for PEVs developing into recognized therapeutic entities. Here, we present an efficient strategy for PEV isolation and bacterial infected wound healing based on self-assembled DNA microflowers. First, DNA microflowers are prepared using rolling circle amplification. Then, the hydrophobic interaction between cholesteryl modified on DNA microflowers and the phospholipid bilayer membrane of PEVs leads to the formation of a network structure with improved mechanical strength and the separation of PEVs from biological samples. Finally, controlled release of PEVs is achieved through bacterial-induced hydrogel degradation.
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