材料科学
对偶(语法数字)
糖肽
调制(音乐)
生物医学工程
纳米技术
医学
化学
生物化学
艺术
哲学
文学类
美学
抗生素
作者
Jiajun Guo,Xiaoguang Zhang,Ruiqi Mao,Hui Li,Yusen Hao,Jiamin Zhang,Wei Wang,Yumin Zhang,Jianfeng Liu
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2024-07-17
标识
DOI:10.1021/acsbiomaterials.4c00698
摘要
The radiation-induced skin injury (RISI) remains a great challenge for clinical wound management and care after radiotherapy, as patients will suffer from the acute radiation injury and long-term chronic inflammatory damage during the treatment. The excessive ROS in the early acute stage and prolonged inflammatory response in the late healing process always hinder therapeutic efficiency. Herein, we developed an extracellular matrix (ECM)-mimetic multifunctional glycopeptide hydrogel (oCP@As) to promote and accelerate RISI repair via a dual-modulation strategy in different healing stages. The oCP@As hydrogel not only can form an ECM-like nanofiber structure through the Schiff base reaction but also exhibits ROS scavenging and DNA double-strand break repair abilities, which can effectively reduce the acute radiation damage. Meanwhile, the introduction of oxidized chondroitin sulfate, which is the ECM polysaccharide-like component, enables regulation of the inflammatory response by adsorption of inflammatory factors, accelerating the repair of chronic inflammatory injury. The animal experiments demonstrated that oCP@As can significantly weaken RISI symptoms, promote epidermal tissue regeneration and angiogenesis, and reduce pro-inflammatory cytokine expression. Therefore, this multifunctional glycopeptide hydrogel dressing can effectively attenuate RISI symptoms and promote RISI healing, showing great potential for clinical applications in radiotherapy protection and repair.
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