生物
安普克
结直肠癌
信号转导
癌症研究
蛋白激酶B
PI3K/AKT/mTOR通路
细胞生物学
肿瘤进展
磷酸化
癌症
遗传学
蛋白激酶A
作者
Weijin Yang,Ruirong Lin,Shen Guan,Yuan Dang,Hongxin He,Xinxiang Huang,Chunkang Yang
出处
期刊:Gene
[Elsevier]
日期:2024-07-08
卷期号:928: 148752-148752
标识
DOI:10.1016/j.gene.2024.148752
摘要
The hepatocyte nuclear factor-1 (HNF1ɑ) is a transcription factor that contributes to several kinds of cancer progression. However, very little is known regarding the mechanisms underlying the activity of HNF1ɑ. We aimed to explore the role of HNF1ɑ in the progress of colorectal cancer (CRC) and elucidate its molecular mechanism. HNF1ɑ expression was upregulated in CRC samples and high expression of HNF1ɑ was associated with poor prognosis of CRC patients. HNF1α knockdown and overexpression inhibited and promoted proliferation, migration and invasion of CRC cells both in vitro and in vivo respectively. Mechanistically, HNF1ɑ increased the transcriptional activity of hexokinase domain component 1(HKDC1)promoter, thus activated AKT/AMPK signaling. Meanwhile, HKDC1 upregulation was important for the proliferation, migration and invasion of CRC cells and knockdown of HKDC1 significantly reversed the proliferation, migration and invasion induced by HNF1α overexpression. Taken together, HNF1ɑ contributes to CRC progression and metastasis through binding to HKDC1 and activating AKT/AMPK signaling. Targeting HNF1ɑ could be a potential therapeutic strategy for CRC patients.
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