丝氨酸
视网膜
外围设备
甘氨酸
细胞生物学
神经科学
功能(生物学)
周围神经
化学
医学
生物
生物化学
解剖
内科学
氨基酸
磷酸化
作者
Esther W. Lim,Regis Fallon,Chris Bates,Yoichiro Ideguchi,Takayuki Nagasaki,Michal K. Handzlik,Emeline Joulia,Roberto Bonelli,Courtney R. Green,Brendan R. E. Ansell,Maki Kitano,Ilham Polis,Amanda J. Roberts,Shigeki Furuya,Rando Allikmets,Martina Wallace,Martin Friedlander,Christian M. Metallo,Marin L. Gantner
标识
DOI:10.1016/j.cmet.2024.07.021
摘要
Metabolic homeostasis is maintained by redundant pathways to ensure adequate nutrient supply during fasting and other stresses. These pathways are regulated locally in tissues and systemically via the liver, kidney, and circulation. Here, we characterize how serine, glycine, and one-carbon (SGOC) metabolism fluxes across the eye, liver, and kidney sustain retinal amino acid levels and function. Individuals with macular telangiectasia (MacTel), an age-related retinal disease with reduced circulating serine and glycine, carrying deleterious alleles in SGOC metabolic enzymes exhibit an exaggerated reduction in circulating serine. A Phgdh
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