Breynia enchengensis , a new species with a narrowly geographic distribution in limestone areas of southwestern Guangxi, China, is described and illustrated. The new species is morphologically similar to B. poomae (Welzen & Chayam.) Welzen & Pruesapan in having creeping stems, ovate to oblong leaf blade, and reddish brown to dark purple flowers, but can be easily distinguished from the latter by the size of the leaf blade and flowers, the number of lateral veins, the habit of the inflorescence, and the shape of the ovary. It also resembles B. lithophila Welzen & Pruesapan in having alternate leaves and in the length/width ratio of leaf blade, but may be distinguished by the presence of hairs throughout the plant, number of lateral veins, length of the pedicle, the habit of the inflorescence, and calyx shape of female flowers. A table to distinguish the new species from B. poomae and B. lithophila , as well as color plates and photos of type specimens of the new species are also provided.