Amyloidosis of the heart: pathophysiology, diagnosis and treatment

Cardiacamyloidosis is characterized by amyloid fibril aggregation due tomisfolded circulating proteins and their deposition in the heart,leading to cardiac damage and dysfunction. Given cardiac amyloidosisis associated with a poor prognosis without treatment, earlydiagnosis and management are critical to increase survival from thedisease. Thisarticle provides an overview of the disease process, diagnosticmodalities, and therapies for cardiac amyloidosis. Recenttechnological advances have led to the development of reliable andaccurate diagnostic modalities for identifying cardiac amyloidosis.Recent introduction of novel disease-modifying therapies for cardiacamyloidosis have resulted in improvements in the management andprognosis of the disease.