基因传递
基因
遗传增强
计算生物学
纳米技术
癌症研究
医学
生物
遗传学
材料科学
作者
Limor Kaneti,Tomer Bronshtein,Natali Malkah Dayan,Inna Kovregina,Nitzan Letko Khait,Yael Lupu‐Haber,Miguel Fliman,Beth Schoen,Galoz Kaneti,Marcelle Machluf
出处
期刊:Nano Letters
[American Chemical Society]
日期:2016-02-24
卷期号:16 (3): 1574-1582
被引量:99
标识
DOI:10.1021/acs.nanolett.5b04237
摘要
Nanoghosts derived from mesenchymal stem cells and retaining their unique surface-associated tumor-targeting capabilities were redesigned as a selective and safe universal nonviral gene-therapy platform. pDNA-loaded nanoghosts efficiently targeted and transfected diverse cancer cells, in vitro and in vivo, in subcutaneous and metastatic orthotopic tumor models, leading to no adverse effects. Nanoghosts loaded with pDNA encoding for a cancer-toxic gene inhibited the growth of metastatic orthotopic lung cancer and subcutaneous prostate cancer models and dramatically prolonged the animals' survival.
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