A nationwide population-based study of Escherichia coli bloodstream infections: incidence, antimicrobial resistance and mortality

医学 入射(几何) 病死率 人口 抗生素耐药性 内科学 死亡率 儿科 抗生素 流行病学 微生物学 生物 环境卫生 光学 物理
作者
Sarah Feldman,Elizabeth Temkin,Liat Wullfhart,Amir Nutman,Vered Schechner,Pnina Shitrit,Racheli Shvartz,Mitchell J. Schwaber,Antoine Andremont,Yehuda Carmeli
出处
期刊:Clinical Microbiology and Infection [Elsevier BV]
卷期号:28 (6): 879.e1-879.e7 被引量:17
标识
DOI:10.1016/j.cmi.2021.12.009
摘要

Escherichia coli is the leading cause of bloodstream infection (BSI). The incidence of E. coli BSI caused by antibiotic-resistant strains is increasing. We aimed to describe the nationwide incidence and resistance profile of E. coli BSI in Israel and its impact on mortality, to compare E. coli BSI mortality with all-cause mortality, and community-onset with hospital-onset E. coli BSIs.We used mandatory BSI surveillance reports submitted by all Israeli hospitals to the Ministry of Health and the national death registry. All E. coli BSIs from 1 January 2018 to 31 December 31 2019 in patients aged 18 and over were included.A total of 11 113 E. coli BSIs occurred in 10 218 patients; 85% (9012/10 583) were community onset. Median age was 76 (IQR 65-85), and 57% (6304/11 113) of cases occurred in women. The annual incidence was 92.5 per 100 000 population. Antibiotic resistance was frequent and significantly more common in hospital-onset than in community-onset BSI; 65% (1021/1571) vs. 45% (4049/9012) were multidrug-resistant (MDR) (p < 0.001). The case fatality rate (CFR) was higher following hospital-onset BSI than community-onset: 23% (276/1214) vs. 12% (926/7620) at 14 days, 31% (378/1214) vs. 16% (1244/7620) at 30 days, and 55% (418/766) vs. 34% (1645/4903) at 1 year (p < 0.001 for all comparisons). The 1-year CFR was 47% (1258/2707) for MDR vs. 28% (928/3281) for non-MDR (p < 0.001). The annual mortality rate was 31.0 per 100 000 population, comprising 4.2% (31.0/734.8) of all causes of deaths.E. coli BSI carries a high burden, with a large proportion of MDR isolates, which are associated with increased incidence and CFR.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
wanmiao12完成签到,获得积分10
1秒前
香蕉觅云应助momo采纳,获得10
3秒前
4秒前
5秒前
爆米花应助李春鸿采纳,获得10
8秒前
LJJ发布了新的文献求助10
9秒前
10秒前
11秒前
12秒前
12秒前
Ava应助YYH采纳,获得10
12秒前
量子星尘发布了新的文献求助10
12秒前
小田心完成签到,获得积分10
12秒前
15秒前
小田心发布了新的文献求助10
15秒前
WYH发布了新的文献求助10
16秒前
一方通行发布了新的文献求助10
16秒前
SherlockHe发布了新的文献求助10
17秒前
FashionBoy应助热情的达采纳,获得10
17秒前
20秒前
lelelele发布了新的文献求助10
21秒前
拜拜完成签到,获得积分10
22秒前
22秒前
扶苏完成签到,获得积分10
22秒前
24秒前
mmm完成签到,获得积分20
25秒前
momo发布了新的文献求助10
25秒前
25秒前
一方通行完成签到,获得积分10
25秒前
xiaosu完成签到,获得积分10
26秒前
小马甲应助yyy采纳,获得10
29秒前
热情的达发布了新的文献求助10
29秒前
Hello应助任性的咖啡采纳,获得10
30秒前
30秒前
墨墨完成签到,获得积分10
30秒前
31秒前
cangy完成签到,获得积分10
32秒前
岸部完成签到,获得积分10
32秒前
在水一方应助WYH采纳,获得10
33秒前
34秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989334
求助须知:如何正确求助?哪些是违规求助? 3531428
关于积分的说明 11253936
捐赠科研通 3270119
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173