Chemical synthesis of TMG-chitotriomycin

TMG-chitotriomycin is a recently discovered β-N-acetylglucosaminidase (GlcNAcase) inhibitor, specific for insect and fungal GlcNAcases. Chemical synthesis is a reliable and effective means to solve the attainability issues of TMG-chitotriomycin, which could facilitate in-depth studies of its biological activities. Thus far, four different synthetic routes toward TMG-chitotriomycin have been reported. Herein, we provide a comprehensive review on the chemical synthesis of TMG-chitotriomycin.