梭菌纲
非甾体
入射(几何)
流行病学
病菌
生物
重症监护医学
感染控制
免疫学
医学
内科学
微生物学
药理学
光学
物理
作者
Joshua Soto Ocaña,Nile U. Bayard,Joseph P. Zackular
标识
DOI:10.1016/j.mib.2021.11.011
摘要
Clostridioides difficile is one of the leading causes of nosocomial infections worldwide. Increases in incidence, severity, and healthcare cost associated with C. difficile infection (CDI) have made this pathogen an urgent public health threat worldwide. The factors shaping the evolving epidemiology of CDI and impacting clinical outcomes of infection are not well understood, but involve tripartite interactions between the host, microbiota, and C. difficile. In addition to this, emerging data suggests an underappreciated role for environmental factors, such as diet and pharmaceutical drugs, in CDI. In this review, we discuss the role of nonsteroidal anti-inflammatory drugs (NSAIDs) and eicosanoids in CDI.
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