骨整合
明胶
涂层
粘附
细胞粘附
生物医学工程
植入
材料科学
间充质干细胞
碱性磷酸酶
化学
表面改性
牙科
纳米技术
细胞生物学
医学
外科
复合材料
生物化学
生物
酶
物理化学
作者
Tingshu Su,Zheng Ao,Lingyan Cao,Lingjie Peng,Xiao Wang,Jie Wang,Xian-Zhen Xin,Xinquan Jiang
标识
DOI:10.1007/s42242-022-00184-5
摘要
Following dental implantation, the characteristic bacterial milieu of the oral cavity may lead to peri-implant inflammation, which can negatively impact osseointegration and cause implant failure. To improve soft tissue sealing around the implant, enhance osseointegration, and improve implant success rates, this paper proposes a composite multifunctional coating (PHG) prepared using gelatin and polydopamine/hydroxyapatite nanoparticles, investigates the effects of this novel coating on cell adhesion, proliferation, antibacterial activity, osteogenic differentiation, and evaluates its immune-related properties. The PHG coating was proved to have satisfactory hydrophilicity and wettability for cell attachment. Furthermore, it improved the expression of adhesion-related genes and proteins in human gingival fibroblasts, indicating its adhesion-promoting effect. Additionally, bone marrow mesenchymal stem cells exhibited strong osteogenic differentiation potential and mineralization on PHG-coated surfaces. Notably, the PHG coating exhibited antibacterial activity against Streptococcus mutans, as well as anti-inflammatory effects, potentially via the regulation of macrophages. Therefore, the proposed PHG coating may promote soft tissue sealing and bone bonding, providing a potential strategy for the surface modification of dental implants.
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