Convenient synthesis of hydroxyapatite-coated ferroferric oxide microspheres by hydrothermal method

In this work, we synthesized hydroxyapatite-coated ferroferric oxide (HA/Fe3O4) microspheres by a convenient hydrothermal method. Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Raman spectroscopy (Raman) and transmission electron microscopy (TEM) confirmed that HA/Fe3O4 microspheres with an average particle size of ∼1 μm were successfully synthesized. The biocompatibility of HA/Fe3O4 samples was evaluated by cell viability and Live/Dead staining of MG-63 cell lines. The experimental results showed that these HA/Fe3O4 microspheres were favorable to proliferation of MG-63 cells. These synthesized microspheres may be potentially attractive biomaterials for bone tissue engineering applications.