药物输送
药品
自愈水凝胶
计算机科学
生化工程
纳米技术
药理学
生物医学工程
风险分析(工程)
医学
化学
材料科学
工程类
有机化学
作者
Margaux Vigata,Christoph Meinert,Dietmar W. Hutmacher,Nathalie Bock
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2020-12-07
卷期号:12 (12): 1188-1188
被引量:159
标识
DOI:10.3390/pharmaceutics12121188
摘要
Owing to their tunable properties, controllable degradation, and ability to protect labile drugs, hydrogels are increasingly investigated as local drug delivery systems. However, a lack of standardized methodologies used to characterize and evaluate drug release poses significant difficulties when comparing findings from different investigations, preventing an accurate assessment of systems. Here, we review the commonly used analytical techniques for drug detection and quantification from hydrogel delivery systems. The experimental conditions of drug release in saline solutions and their impact are discussed, along with the main mathematical and statistical approaches to characterize drug release profiles. We also review methods to determine drug diffusion coefficients and in vitro and in vivo models used to assess drug release and efficacy with the goal to provide guidelines and harmonized practices when investigating novel hydrogel drug delivery systems.
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