TXNIP公司
硫氧还蛋白相互作用蛋白
硫氧还蛋白
调节器
细胞生物学
信号转导
生物
葡萄糖稳态
生物化学
氧化应激
糖尿病
内分泌学
胰岛素抵抗
基因
出处
期刊:Antioxidants
[MDPI AG]
日期:2020-08-18
卷期号:9 (8): 765-765
被引量:78
标识
DOI:10.3390/antiox9080765
摘要
Identification of thioredoxin binding protein-2 (TBP-2), which is currently known as thioredoxin interacting protein (TXNIP), as an important binding partner for thioredoxin (TRX) revealed that an evolutionarily conserved reduction-oxidation (redox) signal complex plays an important role for pathophysiology. Due to the reducing activity of TRX, the TRX/TXNIP signal complex has been shown to be an important regulator for redox-related signal transduction in many types of cells in various species. In addition to its role in redox-dependent regulation, TXNIP has cellular functions that are performed in a redox-independent manner, which largely rely on their scaffolding function as an ancestral α-Arrestin family. Both the redox-dependent and -independent TXNIP functions serve as regulatory pathways in glucose metabolism. This review highlights the key advances in understanding TXNIP function as a master regulator for whole-body glucose homeostasis. The potential for therapeutic advantages of targeting TXNIP in diabetes and the future direction of the study are also discussed.
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