NMDA受体
兴奋剂
蛋白质亚单位
生物物理学
门控
谷氨酸的
受体
化学
AMPA受体
兴奋性突触后电位
神经科学
跨膜结构域
生物
细胞生物学
作者
Gary J. Iacobucci,Han Wen,Matthew Helou,Beiying Liu,Wenjun Zheng,Gabriela K. Popescu
标识
DOI:10.1073/pnas.2007511118
摘要
Significance NMDA receptors are glutamatergic channels whose activation controls the strength of excitatory synapses in the central nervous system. Agonist binding initiates a complex activation reaction that consists of a stepwise sequence of reversible isomerizations. In addition to previously identified steps in this series, which include agonist-induced closure of the ligand-binding lobes and the subsequent mechanical pulling by the ligand-binding domain on the gate-forming transmembrane helix, we identify a cross-subunit interaction that stabilizes open receptors and slows the rate of the current decay. Naturally occurring NMDA receptor variants lacking this interaction are pathogenic.
科研通智能强力驱动
Strongly Powered by AbleSci AI