美罗华
视神经脊髓炎
医学
扩大残疾状况量表
儿科
内科学
回顾性队列研究
脊髓炎
多发性硬化
外科
免疫学
精神科
脊髓
淋巴瘤
作者
Anu Jacob,Brian G. Weinshenker,Ivo Violich,Nancy McLinskey,Lauren B. Krupp,Robert J. Fox,Dean M. Wingerchuk,Mike Boggild,Cris S. Constantinescu,Aaron W. Miller,T. De Angelis,Marcelo Matiello,Bruce A.C. Cree
出处
期刊:Archives of neurology
[American Medical Association]
日期:2008-11-10
卷期号:65 (11): 1443-1443
被引量:432
标识
DOI:10.1001/archneur.65.11.noc80069
摘要
Neuromyelitis optica (NMO) is an uncommon, life-threatening inflammatory demyelinating disorder. Recently, much has become known about its immunopathogenesis. However, optimal treatments, with expected outcomes, have not been established.To evaluate the use and efficacy of rituximab for treating NMO.Retrospective multicenter case series of NMO patients treated with rituximab.Seven tertiary medical centers in the United States and England.Twenty-five patients (including 2 children), 23 of whom experienced relapses despite use of other drugs before rituximab. Extended follow-up of 7 previously reported patients is included.Infusions of rituximab at median intervals of 8 months.Annualized relapse rate and disability (expressed as Expanded Disability Status Scale score).At a median follow-up of 19 months, the median annualized posttreatment relapse rate was lower than the pretreatment rate (0 [range 0-3.2] vs 1.7 [range, 0.5-5] relapses, P < .001). Disability improved or stabilized in 20 of 25 patients (80%, P = .02). Two patients died during the follow-up period, 1 owing to a brainstem relapse and 1 owing to suspected septicemia. Infections were reported in 20% of patients.In NMO, treatment with rituximab appears to reduce the frequency of attacks, with subsequent stabilization or improvement in disability.
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