Serum osteoprotegerin levels and long‐term prognosis in subjects with stable coronary artery disease

骨保护素 医学 内科学 冠状动脉疾病 比例危险模型 心脏病学 前瞻性队列研究 胃肠病学 受体 激活剂(遗传学)
作者
Shuichi Jono,S Otsuki,Yasutomi Higashikuni,Atsushi Shioi,Katsuhito Mori,Kazuhiro Hara,Hideki Hashimoto,Yuji Ikari
出处
期刊:Journal of Thrombosis and Haemostasis [Elsevier BV]
卷期号:8 (6): 1170-1175 被引量:39
标识
DOI:10.1111/j.1538-7836.2010.03833.x
摘要

Osteoprotegerin (OPG) is a secretory glycoprotein which belongs to the tumor necrosis factor receptor family. OPG immunoreactivity was demonstrated in normal blood vessels and in early atherosclerotic lesions. In a previous study, we showed that high serum OPG levels are associated with progression of coronary artery disease (CAD).The present study was designed to assess the association between serum OPG level and long-term prognosis in patients with stable coronary artery disease.We performed a prospective, observational cohort study in 225 subjects to examine whether serum OPG levels can predict cardiovascular mortality. The median OPG levels were 1.02 ng mL(-1) at baseline.During the follow-up (61 + or - 25 months), 27 deaths occurred including 13 cardiovascular deaths. When the subjects were divided into three groups according to serum OPG level, the group with high serum OPG showed a higher risk for cardiovascular mortality. A Multivariate Cox proportional hazards model indicated that the higher risk of cardiovascular death in the high OPG level group remained significant (hazards ratio of 7.44, 95%CI 0.92-60.30, highest vs. lowest OPG tertile). In contrast, serum OPG levels were not associated with non-cardiovascular mortality.Our data show that serum OPG levels are an independent predictor of cardiovascular mortality in patients with stable coronary artery disease.
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