雪旺细胞
材料科学
体外
生物医学工程
细胞
神经导管
纳米技术
细胞生物学
生物物理学
周围神经
解剖
生物
医学
生物化学
遗传学
作者
Ahmet Bozkurt,Ronald Deumens,Christina Beckmann,Leon Olde Damink,Frank Schügner,I. Heschel,Bernd Sellhaus,Joachim Weis,Willi Jahnen-Dechent,Gary Brook,Norbert Pallua
出处
期刊:Biomaterials
[Elsevier]
日期:2009-01-01
卷期号:30 (2): 169-179
被引量:164
标识
DOI:10.1016/j.biomaterials.2008.09.017
摘要
Therapeutic benefits of autologous nerve grafting in repair of peripheral nerve lesions have not been reached using any alternative nerve guide. Nevertheless, issues of co-morbidity and limited availability of donor nerves urgently ask for a need of bioartificial nerve guides which could either replace or complement autologous nerve grafts. It is increasingly appreciated that optimal nerve guides comprise both physical and molecular cues in support of peripheral axon regeneration. Now, we present a collagen-based microstructured 3D nerve guide containing numerous longitudinal guidance channels with dimensions resembling natural endoneurial tubes. Moreover, these nerve guides could be functionalized by Schwann cell (SC) seeding. Viable SCs did not only adhere to the nerve guide, but also migrated throughout the guidance channels. Of particular importance was the observation that SCs within the guidance channels formed cellular columns reminiscent of “Bands of Büngner”, which are crucial structures in the natural process of peripheral nerve regeneration during the Wallerian degeneration. We, therefore, conclude that our orientated 3D nerve guides (decorated with SCs) with their physical and molecular properties may hold great promise in the repair of peripheral nerve lesion and serve as a basis for future experimental regeneration studies.
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