细胞骨架
细胞生物学
伤口愈合
生物
多细胞生物
胚胎干细胞
细胞迁移
细胞
免疫学
遗传学
基因
作者
María Teresa Abreu-Blanco,James J. Watts,Jeffrey M. Verboon,Susan M. Parkhurst
标识
DOI:10.1007/s00018-012-0928-2
摘要
Wound repair on the cellular and multicellular levels is essential to the survival of complex organisms. In order to avoid further damage, prevent infection, and restore normal function, cells and tissues must rapidly seal and remodel the wounded area. The cytoskeleton is an important component of wound repair in that it is needed for actomyosin contraction, recruitment of repair machineries, and cell migration. Recent use of model systems and high-resolution microscopy has provided new insight into molecular aspects of the cytoskeletal response during wound repair. Here we discuss the role of the cytoskeleton in single-cell, embryonic, and adult repair, as well as the striking resemblance of these processes to normal developmental events and many diseases.
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