先天免疫系统
生物
表观遗传学
组蛋白
染色质
转录因子
免疫学
脂多糖
细胞生物学
免疫系统
炎症
基因
遗传学
作者
Koshi Yoshida,Tomoko Maekawa,Yujuan Zhu,Claire Renard-Guillet,Bruno Chatton,Kentaro Inoue,Takuro Uchiyama,Kenichi Ishibashi,Takuji Yamada,Naohito Ohno,Katsuhiko Shirahige,Mariko Okada,Shunsuke Ishii
出处
期刊:Nature Immunology
[Springer Nature]
日期:2015-08-31
卷期号:16 (10): 1034-1043
被引量:153
摘要
Immunological memory is thought to be mediated exclusively by lymphocytes. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection, which suggests the presence of innate immunological memory. Here we identified an important role for the stress-response transcription factor ATF7 in innate immunological memory. ATF7 suppressed a group of genes encoding factors involved in innate immunity in macrophages by recruiting the histone H3K9 dimethyltransferase G9a. Treatment with lipopolysaccharide, which mimics bacterial infection, induced phosphorylation of ATF7 via the kinase p38, which led to the release of ATF7 from chromatin and a decrease in repressive histone H3K9me2 marks. A partially disrupted chromatin structure and increased basal expression of target genes were maintained for long periods, which enhanced resistance to pathogens. ATF7 might therefore be important in controlling memory in cells of the innate immune system.
科研通智能强力驱动
Strongly Powered by AbleSci AI