肾病
发病机制
局灶节段性肾小球硬化
免疫学
疾病
肾小球硬化
病毒
人口
医学
病毒学
生物
肾
肾小球肾炎
病理
内科学
蛋白尿
糖尿病
内分泌学
环境卫生
作者
Elizabeth S. Herman,Paul E. Klotman
标识
DOI:10.1053/snep.2003.50018
摘要
Initially described in 1984, human immunodeficiency virus-associated nephropathy (HIVAN) has now become a common disease within the HIV-seropositive population. It is a focal segmental glomerulosclerosis causing rapid deterioration of renal function. It is the most common cause of chronic renal disease in HIV patients and occurs almost exclusively in blacks. Through murine and human studies, it is now clear that HIVAN is caused by a direct effect of infection of renal cells by HIV-1 and that the virus actively replicates within renal cells. How the virus causes disease within cells is not yet understood, but there is evidence for factors within infected cells causing both proliferation and apoptosis. Steroids, angiotensin converting enzyme (ACE) inhibitors, and highly active antiretroviral therapy (HAART) have been used for the treatment of HIVAN, with HAART, in particular, showing a dramatic improvement in both the pathologic changes and clinical course of HIVAN. © 2003 Elsevier Inc. All rights reserved.
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