化学
生物碱
药理学
立体化学
组合化学
药物发现
作者
Sebastian Clementson,Sergio Armentia Matheu,Emil Märcher Rørsted,Henrik Pedersen,Anders A. Jensen,Rasmus P. Clausen,Paulo Jorge Vieira Vital,Emil Glibstrup,Mikkel Jessing,Jesper L. Kristensen
标识
DOI:10.1021/acs.joc.1c00707
摘要
Erythrina alkaloids and their central nervous system effects have been studied for over a century, mainly due to their potent antagonistic actions at β2-containing nicotinic acetylcholine receptors (nAChRs). In the present work, we report a synthetic approach giving access to a diverse set of Erythrina natural product analogues and present the enantioselective total synthesis of (+)-Cocculine and (+)-Cocculidine, both found to be potent antagonists of the β2-containing nAChRs.
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