微泡
生物制药
内吞循环
计算生物学
外体
纳米技术
内吞作用
生物
细胞
生物技术
小RNA
材料科学
遗传学
生物化学
基因
作者
Nimeet Desai,Anuradha Gadeval,Umesh Kathar,Pinaki Sengupta,Kiran Kalia,Rakesh K. Tekade
标识
DOI:10.1016/j.jddst.2021.102577
摘要
Exosomes are bilayer nanovesicles of endocytic origin engaged in intercellular communication through functionally active and cell-specific cargo (such as proteins, lipids, and RNAs). Owing to their small size (in the range of 30–100 nm) and attributes like long circulation half-life, inter-species biocompatibility, cell-targeting potential, and the capability to carry/deliver macromolecular cargo, exosomes have been subject to tremendous interest in the pharmaceutical field for their potential application as therapeutic delivery vehicles and non-invasive diagnostic biomarkers. Of all available biofluids that can act as a potential source to derive exosomes, mammalian milk has garnered substantial interest considering its safety, bulk availability, and cost-effectiveness. This review focuses on understanding milk-derived exosomes, emphasizing their sources, isolation approaches, proteomics, stability, and recent advances in their therapeutic applications.
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