涂层
药物输送
化妆品
材料科学
纳米技术
生化工程
化学
化学工程
有机化学
作者
Sumel Ashique,Ajmer Singh,Sumel Ashique
出处
期刊:Recent Patents on Nanotechnology
日期:2021-03-15
标识
DOI:10.2174/1872210515666210316104149
摘要
: Oleosomes are oil containing micro-carriers of natural origin that is comprised of special Oleosin proteins embedded with a monolayer of phospholipids and having triacylglycerol core. Due to their unique structure and non-toxic to the biological system these oil carriers are becoming very eye-catching in the field of formulation development in the field of pharmacy. Consequently, it offers emoliency, occlusivity, self-emulsification, an antioxidant and film-forming property which leads to controlled and sustained release of encapsulated bio-actives. It is also feasible to load oil-soluble ingredients such as fragrance, vitamins (retinol), and lipophilic drug moieties inside the core. Being a natural carrier, it shows some stability issues (leakage of oil from the core, oxidation of the loaded oil, aggregation of oil droplets) which are controllable. In this review, we have focused on the various stability issues, techniques (coating, surface modification, solvents) to overcome those problems, how to load any lipophilic drug into the oil core, and linked patent research works in the field of formulation development.
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