因果推理
混淆
2019年冠状病毒病(COVID-19)
授权
可识别性
相对风险
估计
统计推断
推论
结果(博弈论)
医学
精算学
计量经济学
人口学
公共卫生
统计
置信区间
计算机科学
经济
政治学
数学
内科学
法学
社会学
人工智能
护理部
管理
传染病(医学专业)
数理经济学
疾病
作者
Alex M. H. Wong,Laura B. Balzer
出处
期刊:Epidemiology
[Openventio Publishers]
日期:2022-03-01
卷期号:33 (2): 228-236
被引量:5
摘要
We sought to investigate the effect of public masking mandates in US states on COVID-19 at the national level in Fall 2020. Specifically, we aimed to evaluate how the relative growth of COVID-19 cases and deaths would have differed if all states had issued a mandate to mask in public by 1 September 2020 versus if all states had delayed issuing such a mandate.We applied the Causal Roadmap, a formal framework for causal and statistical inference. We defined the outcome as the state-specific relative increase in cumulative cases and in cumulative deaths 21, 30, 45, and 60 days after 1 September. Despite the natural experiment occurring at the state-level, the causal effect of masking policies on COVID-19 outcomes was not identifiable. Nonetheless, we specified the target statistical parameter as the adjusted rate ratio (aRR): the expected outcome with early implementation divided by the expected outcome with delayed implementation, after adjusting for state-level confounders. To minimize strong estimation assumptions, primary analyses used targeted maximum likelihood estimation with Super Learner.After 60 days and at a national level, early implementation was associated with a 9% reduction in new COVID-19 cases (aRR = 0.91 [95% CI = 0.88, 0.95]) and a 16% reduction in new COVID-19 deaths (aRR = 0.84 [95% CI = 0.76, 0.93]).Although lack of identifiability prohibited causal interpretations, application of the Causal Roadmap facilitated estimation and inference of statistical associations, providing timely answers to pressing questions in the COVID-19 response.
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