Antibiotic pollution is a serious global problem, which may threaten the health of human and ecosystem. Thereinto, water pollution is the most common way. Thus, it is necessary to develop effective methods to remove antibiotics from the natural aqueous environments. Metal-organic Frameworks (MOFs) - based adsorption and photocatalysis strategies have been demonstrated to be efficient, environmental and promising methods to solve antibiotic pollution and repair the environment. In this review, several strategies to improve the properties of MOFs for removal were summarized and discussed. And the removal mechanisms were also discussed. Besides, new and more reliable evaluation methods of MOFs to remove antibiotics were presented, including preferential adsorption (qp), quantum yields (QY), space time yields (SY) and figure of merit (FOM). This paper provides alternative perspectives for researchers to improve the properties of MOFs and raise analytic efficiency of antibiotic removal.