生物
细胞
细胞生物学
效应器
细胞生长
先天免疫系统
T细胞
免疫学
细胞分化
免疫系统
基因
计算生物学
遗传学
作者
Weihong Gu,Weihong Gu,Sebastian Joyce,John P. Driver
出处
期刊:Cell Reports
[Elsevier]
日期:2022-07-01
卷期号:40 (1): 111050-111050
被引量:17
标识
DOI:10.1016/j.celrep.2022.111050
摘要
Many aspects of the porcine immune system remain poorly characterized, which poses a barrier to improving swine health and utilizing pigs as preclinical models. Here, we employ single-cell RNA sequencing (scRNA-seq) to create a cell atlas of the early-adolescent pig thymus. Our data show conserved features as well as species-specific differences in cell states and cell types compared with human thymocytes. We also describe several unconventional T cell types with gene expression profiles associated with innate effector functions. This includes a cell census of more than 11,000 differentiating invariant natural killer T (iNKT) cells, which reveals that the functional diversity of pig iNKT cells differs substantially from the iNKT0/1/2/17 subset differentiation paradigm established in mice. Our data characterize key differentiation events in porcine thymopoiesis and iNKT cell maturation and provide important insights into pig T cell development.
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