已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Long-term prognostic significance of HER2-low and HER2-zero in node-negative breast cancer

医学 免疫组织化学 内科学 乳腺癌 曲妥珠单抗 精确检验 肿瘤科 比例危险模型 分级(工程) 人表皮生长因子受体2 胃肠病学 HER2/东北 队列 癌症 病理 生物 生态学
作者
Katrin Almstedt,Anne-Sophie Heimes,Franziska Kappenberg,Marco Johannes Battista,Hans‐Anton Lehr,Slavomir Krajnak,Antje Lebrecht,Mathias Gehrmann,Kathrin Stewen,Walburgis Brenner,W. Weikel,Jörg Rahnenführer,Jan G. Hengstler,Annette Hasenburg,Marcus Schmidt
出处
期刊:European Journal of Cancer [Elsevier BV]
卷期号:173: 10-19 被引量:59
标识
DOI:10.1016/j.ejca.2022.06.012
摘要

Recently, novel antibody--drug conjugates (ADCs) showed clinical activity in a subset of advanced human epidermal growth factor receptor 2 (HER2)-negative patients. We investigated the prognostic significance of HER2-low and HER2-zero tumours.The retrospective cohort study included 410 consecutive node-negative breast cancer patients without adjuvant systemic therapy treated between 1985 and 2000 (median follow-up: 16.73 [IQR 8.58-23.45] years). 351 (85.6%) were HER-2 negative and subdivided into HER2-zero (immunohistochemistry [IHC] score 0) and HER2-low (IHC score 1+ or 2+/in situ hybridisation [ISH]-negative). HER2 gene expression was available in 170 (48.4%) patients. Differences in HER2 status for immunohistochemistry, gene expression and clinico-pathologic parameters were assessed using Fisher's exact test, Pearson's correlation and Mann-Whitney test. Prognosis was investigated using the Kaplan-Meier method and Cox regression analyses.Of the 351 HER2-negative patients, 198 (56.4%) had HER2-low tumours and 153 (43.6%) were HER2-zero. Significant differences between HER2-zero and HER2-low tumours were found in histologic grading (P = 0.001), Ki-67 (P = 0.013) and HER2 gene expression (P = 0.002). HER2-low patients had significantly longer disease-free survival (DFS) (15-year rate: 67.5% [95% CI 61.0-74.7] vs. 47.3% [95% CI 39.9-56.1], P < 0.001) and overall survival (OS) (15-year rate: 75.4% [95% CI 69.4-81.9] vs. 66.8% [95% CI 59.5-74.9], P = 0.009). The OS difference was observed in hormone receptor (HR)-positive (P = 0.039) but not HR-negative (P = 0.086) tumours. The results of multivariable analyses confirmed the independent prognostic significance of HER2 status (DFS: HR, 0.546; 95% CI, 0.402-0.743; P < 0.001; OS: HR, 0.653; 95% CI, 0.458-0.932; P = 0.019).HER2-low patients had a better survival than HER2-zero patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
喜悦香薇完成签到 ,获得积分10
2秒前
3秒前
6秒前
俊逸海豚完成签到 ,获得积分10
7秒前
隐形曼青应助chen采纳,获得10
8秒前
kangw完成签到,获得积分20
9秒前
曹大壮发布了新的文献求助10
10秒前
小谢完成签到,获得积分10
11秒前
饭ff发布了新的文献求助10
11秒前
执着的冬瓜完成签到 ,获得积分10
11秒前
13秒前
14秒前
DAYDAY完成签到 ,获得积分10
19秒前
19秒前
xcf驳回了orixero应助
20秒前
Nowind发布了新的文献求助10
21秒前
22秒前
23秒前
111完成签到,获得积分10
23秒前
健壮保温杯完成签到,获得积分10
26秒前
东华帝君完成签到,获得积分10
26秒前
漂亮白枫发布了新的文献求助10
28秒前
Nowind完成签到,获得积分10
29秒前
30秒前
31秒前
32秒前
曹大壮完成签到,获得积分10
32秒前
兆兆完成签到 ,获得积分10
34秒前
edisondc发布了新的文献求助10
35秒前
菜头完成签到,获得积分10
38秒前
40秒前
42秒前
Smiling应助文茵采纳,获得10
43秒前
星辰大海应助饭ff采纳,获得10
43秒前
45秒前
wab完成签到,获得积分0
45秒前
酷波er应助雪白的夏山采纳,获得10
47秒前
leezh完成签到,获得积分10
48秒前
Trtr7985发布了新的文献求助10
49秒前
慕青应助漂亮白枫采纳,获得10
50秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989868
求助须知:如何正确求助?哪些是违规求助? 3531994
关于积分的说明 11255752
捐赠科研通 3270793
什么是DOI,文献DOI怎么找? 1805053
邀请新用户注册赠送积分活动 882215
科研通“疑难数据库(出版商)”最低求助积分说明 809208