Clinical Characteristics of Potential “Difficult-to-treat” Patients with Psoriatic Arthritis: A Retrospective Analysis of a Longitudinal Cohort

医学 银屑病性关节炎 共病 内科学 回顾性队列研究 纤维肌痛 队列 类风湿性关节炎 物理疗法 疾病 队列研究 纵向研究 病理
作者
Fabio Massimo Perrotta,Silvia Scriffignano,Francesco Ciccia,Ennio Lubrano
出处
期刊:Rheumatology and therapy [Springer Nature]
卷期号:9 (4): 1193-1201 被引量:28
标识
DOI:10.1007/s40744-022-00461-w
摘要

The EULAR group recently published the definition of difficult-to-treat (D2T) patients for rheumatoid arthritis. However, a similar definition is lacking for patients with psoriatic arthritis (PsA), in which its multi-domain expression may impact the treatment response. The aim of the study was to characterize the potential D2T PsA patients, to assess the risk factors, and to determine the burden of disease.Retrospective analysis of a longitudinal cohort of PsA patients attending a tertiary care center. At each visit, the patients underwent a complete physical examination and the clinical/laboratory data were collected. Data on comorbidities with the assessment of different comorbidity indices were also collected. Disease activity was assessed by using the DAPSA score and the MDA. The PsAID and HAQ-DI were also collected. We use the previous identified definition of D2T patients, applied to our PsA group and modified for this study.A total of 106 patients fulfilled the inclusion criteria and were evaluated. Of these, 36 (33.9%) patients fulfilled the criteria for the potential D2T patients. D2T patients showed a significantly higher BMI and higher prevalence of fibromyalgia. Furthermore, D2T patients showed a significantly higher median Functional Comorbidity Index and a significantly higher BSA, LEI, pain level, PsAID score, and HAQ-DI than non-D2T patients. Potential D2T patients also showed a significant delay in the time from diagnosis to first b/ts DMARDs treatment.Our study firstly evaluated the presence of clinical characteristics of potential D2T patients and may contribute to future research on this intriguing aspect.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
隐形曼青应助七海之风采纳,获得10
2秒前
4秒前
Lucas应助88采纳,获得10
4秒前
小二郎应助科研通管家采纳,获得10
5秒前
隐形曼青应助科研通管家采纳,获得10
5秒前
cyrong应助科研通管家采纳,获得10
5秒前
爱学习发布了新的文献求助10
5秒前
bkagyin应助科研通管家采纳,获得10
5秒前
坦率耳机应助科研通管家采纳,获得20
5秒前
Severan完成签到,获得积分10
5秒前
Owen应助科研通管家采纳,获得10
5秒前
Arylkunst完成签到,获得积分10
6秒前
李健应助顾磊磊采纳,获得10
7秒前
7秒前
今后应助鹿lu采纳,获得10
7秒前
8秒前
hanxiaoxin完成签到,获得积分10
9秒前
研玲完成签到,获得积分10
9秒前
9秒前
追寻的易巧完成签到 ,获得积分10
10秒前
路痴完成签到,获得积分10
11秒前
mei发布了新的文献求助10
11秒前
12秒前
烟花应助彭凯采纳,获得10
12秒前
RN完成签到,获得积分10
14秒前
14秒前
大晨发布了新的文献求助10
18秒前
小回发布了新的文献求助10
21秒前
21秒前
23秒前
24秒前
战战完成签到,获得积分10
25秒前
25秒前
wen发布了新的文献求助10
26秒前
27秒前
Hello应助鲁西西采纳,获得10
28秒前
陈宝妮完成签到,获得积分10
29秒前
hercasewhite完成签到,获得积分10
29秒前
GengYing发布了新的文献求助10
29秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Pharmacogenomics: Applications to Patient Care, Third Edition 1000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
《粉体与多孔固体材料的吸附原理、方法及应用》(需要中文翻译版,化学工业出版社,陈建,周力,王奋英等译) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3084504
求助须知:如何正确求助?哪些是违规求助? 2737517
关于积分的说明 7545573
捐赠科研通 2387170
什么是DOI,文献DOI怎么找? 1265830
科研通“疑难数据库(出版商)”最低求助积分说明 613169
版权声明 598336