[Effect of transcutaneous electrical acupoint stimulation on epidural-related maternal fever in parturients undergoing epidural labor analgesia].

To evaluate the therapeutic effect and safety of transcutaneous electrical acupoint stimulation (TEAS) on epidural-related maternal fever in parturients undergoing epidural labor analgesia.A total of 198 primiparas with single birth, full-term pregnancy and head position were recruited and randomized into a TEAS group (98 cases) and a control group (100 cases). In the TEAS group, after epidural labor analgesia, TEAS was applied to bilateral Hegu (LI4) and Quchi (LI11), once an hour, for 30 min each time, till the end of childbirth. In the control group, after epidural labor analgesia, TEAS electrodes were attached to the same acupoints, but without electric stimulation. Maternal tympanic temperature and the score of Visual Analogue Score (VAS) were measured before analgesia, at 1, 2, 3, 4 and 5 h after analgesia and during labor respectively and maternal fever rate was evaluated in the parturients of two groups. Separately, before analgesia, 2 h after analgesia and during labor, the levels of serum interleukin (IL-6) and IL-1β were determined in the parturients of two groups. The duration of labor, the mode of labor, oxytocin dosage, postpartum hemorrhage, neonatal Apgar scores, time of labor analgesia, labor analgesic consumption and adverse effects were recorded in the parturients of two groups.Maternal tympanic temperature increased progressively in two groups as analgesic time prolonged. Tympanic temperature at 3, 4 and 5 h after analgesia and du-ring labor, and maternal fever rate during labor in the TEAS group were all lower than those in the control group respectively (P<0.05). The levels of serum IL-6 and IL-1β increased after analgesia in the parturients of two groups. The serum IL-6 level during labor and the level of IL-1β at 2 h after analgesia and during labor in the parturients of the TEAS group were lower than those in the control group (P<0.05). The analgesic consumption in the TEAS group was less than that in the control group (P<0.05). The incidence of chills in the TEAS group was lower than that in the control group (P<0.05). The differences were not statistical in VAS score, duration of labor, mode of labor, oxytocin dosage, postpartum hemorrhage, time of labor analgesia and neonatal Apgar score, as well as the incidence of urine retention, nausea and vomiting and urinary retention between two groups (P>0.05).Transcutaneous electrical acupoint stimulation at LI11 and LI4 is conductive to relieving epidural-rela-ted maternal fever and reducing serum levels of IL-6 and IL-1β in the parturients undergoing epidural labor analgesia. It is safe and effective in clinical application.目的：探讨经皮穴位电刺激对硬膜外分娩镇痛相关产时发热的疗效及安全性。方法：选择单胎、足月、头位妊娠初产妇198例，随机分为电刺激组98例和对照组100例。电刺激组产妇实施硬膜外分娩镇痛后，经皮穴位电刺激曲池和合谷，每小时刺激1次，每次30 min，直至分娩结束。对照组产妇实施硬膜外分娩镇痛后，相同穴位处连接电极但不予电刺激。测量两组产妇镇痛前，镇痛后1、2、3、4、5 h及分娩时的鼓膜温度、疼痛视觉模拟量尺(VAS)评分并评估产时发热率。测定两组产妇镇痛前、镇痛后2 h及分娩时血清白细胞介素6(IL-6)和白细胞介素1β(IL-1β)水平。记录两组产妇产程、分娩方式、催产素用量、产后出血量、新生儿Apgar评分、分娩镇痛时间、分娩镇痛药量、不良反应。结果：两组产妇鼓膜温度随着分娩镇痛时间的延长均较镇痛前有所升高，电刺激组产妇镇痛后3、4、5 h及分娩时的鼓膜温度及产时发热率均较对照组降低(P<0.05)。两组产妇镇痛后的血清IL-6、IL-1β水平较镇痛前升高；电刺激组产妇分娩时血清IL-6水平、镇痛后2 h及分娩时血清IL-1β水平均较对照组降低(P<0.05)。电刺激组分娩镇痛药量、寒战发生率低于对照组(P<0.05)。两组产妇VAS评分、分娩方式、分娩镇痛时间、催产素用量、产后出血量、产程、新生儿Apgar评分等指标及尿潴留、恶心、呕吐发生率差异无统计学意义(P＞0.05)。结论：经皮穴位电刺激曲池和合谷有助于缓解硬膜外分娩镇痛相关产时发热，降低产妇血清IL-6、IL-1β水平，临床应用安全有效。.