止血
海绵
止血剂
凝血时间
化学
壳聚糖
体内
溶血
血小板
凝结
生物相容性
体外
细胞毒性
凝血
生物物理学
生物医学工程
生物化学
外科
免疫学
内科学
医学
生物
有机化学
生物技术
植物
作者
Xiaojie Sun,Jing Li,Kai Shao,Dan Wang,Shichao Bi,Yuzhi Mu,Kaichao Zhang,Zheng Cao,Li Wang,Xiguang Chen,Chao Feng
标识
DOI:10.1016/j.ijbiomac.2021.05.123
摘要
Rapid control of bleeding is of great significance in military trauma and traffic accidents. In this study, alkylated chitosan (AC) and diatom biosilica (DB) were combined to develop a safe and effective hemostatic composite sponge (AC-DB sponge) for hemorrhage control. Due to the procoagulant chemical structure of AC-DB sponge, it exhibited rapid hemostatic ability in vitro (clotting time was shortened by 78% than that of control group), with favorable biocompatibility (hemolysis ratio < 5%, no cytotoxicity). The strong interface effect between AC-DB sponge and blood induced the erythrocyte and platelets activation, deformation and aggregation, intrinsic coagulation pathway activation, resulting in significant coagulation acceleration. AC-DB sponge had excellent performance in in vivo assessments with shortest clotting time (106.2 s) and minimal blood loss (328.5 mg). All above results proved that AC-DB sponge had great potential to be a safe and rapid hemostatic material.
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