医学
多发性骨髓瘤
峰度
接收机工作特性
单变量
核医学
单变量分析
骨髓
多元分析
有效扩散系数
多元统计
内科学
放射科
肿瘤科
磁共振成像
统计
数学
作者
Qin Wang,Lu Zhang,Sheng Li,Hao Sun,Xia Wu,Ailin Zhao,Thomas Benkert,Daobin Zhou,Huadan Xue,Zhengyu Jin,Li J
标识
DOI:10.1016/j.acra.2021.07.010
摘要
The revised International Staging System (R-ISS) is the current risk stratifier for patients with newly diagnosed multiple myeloma (NDMM). We used histogram analysis based on apparent diffusion coefficient (ADC) maps of bone marrow to predict high-risk NDMM patients staged as R-ISS stage III.Sixty-one NDMM patients were recruited prospectively and underwent whole-body diffusion-weighted MRI. Mean ADC and four ADC-based histogram parameters of representative background bone marrow were quantified with TexRAD software, including ADC entropy, ADC standard deviation (SD), ADC skewness and ADC kurtosis. Diagnostic performance to discriminate R-ISS III from I/II disease was evaluated by receiver-operating characteristics curve (ROC). Univariate and multivariate analysis using stepwise logistic regression model was performed to identify predictors for R-ISS III.ADC entropy of background marrow showed the highest areas under the ROC (0.784, sensitivity = 93.3%, specificity = 63.0%) for the detection of R-ISS stage III disease. Multivariate analysis showed that increased ADC entropy (>3.612) of background marrow can independently predict R-ISS stage III disease in the overall patients (Model 1 corrected for diffuse infiltration [DI] pattern: odds ratio [OR], 10.647; p = 0.008; Model 2 corrected for mean ADC: OR, 10.485; p = 0.010) and in the subgroup with DI pattern (OR, 7.043; p = 0.037).ADC entropy of background marrow may serve as a sensitive imaging biomarker facilitating the detection of high-risk NDMM patients staged as R-ISS stage III. Increased ADC entropy of background marrow can independently predict R-ISS stage III in the overall patients and in the subgroup with DI pattern.
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