降钙素原
败血症
医学
C反应蛋白
新生儿败血症
抗生素
急性期蛋白
内科学
血培养
重症监护医学
儿科
炎症
生物
微生物学
作者
Águeda Molinero‐Fernández,María Moreno‐Guzmán,Luis Arruza,Miguel Ángel López,Alberto Escarpa
出处
期刊:ACS Sensors
[American Chemical Society]
日期:2019-07-15
卷期号:4 (8): 2117-2123
被引量:43
标识
DOI:10.1021/acssensors.9b00890
摘要
Early diagnosis of sepsis, combining blood cultures and inflammation biomarkers, continues to be a challenge, especially in very low birth weight (VLBW) infants because of limited availability of blood samples. Traditional diagnostic procedures are cumbersome, not fast enough, and require relatively large volumes of sample. Empiric use of antibiotics, before diagnostic confirmation, is required to decrease mortality, leading to potential antibiotic resistance and side effects in VLBW infants. To solve such a serious problem, a dual magnetoimmunosensor is proposed for simultaneous assessment of two of the most important sepsis biomarkers: procalcitonin (PCT for early phase) and C-reactive protein (CRP for late phase). This "sample-to-result" approach exhibited excellent sensitivity, selectivity, precision, and stability using low sample volumes (<30 μL) and under 20 min of total assay. The analytical usefulness of the approach was demonstrated by analyzing clinically relevant samples of preterm neonates with suspicion of sepsis.
科研通智能强力驱动
Strongly Powered by AbleSci AI