染色质
生物
折叠(DSP实现)
计算生物学
染色体
DNA
染色体构象捕获
基因
弦(物理)
高分子物理
遗传学
基因表达
聚合物
物理
增强子
电气工程
工程类
核磁共振
量子力学
作者
Simona Bianco,Andrea M. Chiariello,Mattia Conte,Andrea Esposito,Luca Fiorillo,Francesco Musella,Mario Nicodemi
标识
DOI:10.1016/j.ceb.2020.01.002
摘要
Microscopy and sequencing-based technologies are providing increasing insights into chromatin architecture. Nevertheless, a full comprehension of chromosome folding and its link with vital cell functions is far from accomplished at the molecular level. Recent theoretical and computational approaches are providing important support to experiments to dissect the three-dimensional structure of chromosomes and its organizational mechanisms. Here, we review, in particular, the String&Binders polymer model of chromatin that describes the textbook scenario where contacts between distal DNA sites are established by cognate binders. It has been shown to recapitulate key features of chromosome folding and to be able at predicting how phenotypes causing structural variants rewire the interactions between genes and regulators.
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