生物
头发周期
磷酸化
细胞生物学
膜联蛋白A1
MAPK/ERK通路
表皮生长因子
膜联蛋白
信号转导
毛囊
内科学
内分泌学
受体
生物化学
细胞
医学
作者
Hao Zhang,Xiaoqiao Fu,Yue Ao,Miaomiao Nan,Ziyu Qiu,Xiuzhi Jia,Ying Xiao,Dongjun Liu,Xudong Guo
出处
期刊:Gene
[Elsevier]
日期:2021-03-01
卷期号:771: 145343-145343
被引量:4
标识
DOI:10.1016/j.gene.2020.145343
摘要
Annexin A1 (ANXA1), a calcium-dependent phospholipid binding protein expressed in animals, plants and microorganisms, participates in various cellular physiological activities. Previous proteomics analysis indicates that the level of ANXA1 in mice dorsal skin changes during hair growth cycle, we speculate that ANXA1 may play an important role in hair follicle (HF) development. Thus, Anxa1 knock-out (KO) and over-expression (OE) mice were constructed to test its function. Our results showed that in addition to the diameter of HF and hair shaft, ANXA1 could participate in hair growth by affecting the density of HF, and the proliferation of hair follicle stem cells (HFSCs). Meanwhile, molecular analysis showed that EGF signaling pathway is involved in the function of ANXA1. The expression of Anxa1 is negatively correlated with the levels of Egf, Notch1, Mkk7, and phosphorylated AKT1 and ERK/2 proteins. The levels of Egf, Notch1, Mkk7 and phosphorylation of AKT1 and ERK/2 increased in Anxa1 KO mice but decreased in Anxa1 OE mice. Taken together, our results suggested that ANXA1 could affect the hair growth by regulating the HFSCs proliferation through EGF signaling pathway.
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